Table 1.

The highest scoring alignments identified between epitopes identified on human endogenous retroviruses (HERVS) and host autoantigens.

HERV/protein	Accession	Autoantigen	Accession	Shared identity/non-residues
HERV-K10 Gag1*	M14123	Collagen II	NP_001835	5
HERV-K Gag**	M14123	Calpastatin	NP_001741	7+/4+
		Collagen I	NP_000080
HERV-K10 Gag2	M14123	70 kDa Ku antigen		5++
HERV-K10 Pol/Env	M14123	DNA topoisomerase I	NP_003277	5+
HERV-K10 Pol/Env	M14123	Heat shock protein 90	NP_005339	4+
HERV-K10 Pol/Env	M14123	U1	P08621	7+
HERV-K10 Pol/Env	M14123	70 kDa Ku antigen	AAH72449	5+
HERV-K10 Pol/Env	M14123	AHNAK	NP_001611	7
HERV-K Env	Y18890	DNA topoisomerase I	NP_003277	5+
ERV3 Pol	M12140	52 kDa SS-A/Ro	NP_003132	5
ERV-3 Env	M12140	G6PI	P06744	6++
HERV-E(4-1) Gag	M10976	Ku 86/90	P13010	6
HERV-E(4-1) Gag	M10976	MMP-1	NP_002412	5
HERV-E(4-1) Gag	M10976	Histone 1	NM_005319	5+
HERV-E(4-1) Pol	M10976	RA-47	NP_001226	5
HRES-1 p25	X16660	Collagen II	NP_001835	8+++

Accession numbers indicate allocations within National Center for Biotechnology Information (NCBI) database. Shared identity numbers indicate the number of amino acid residues shared between both. +: Partial match between residues.

^*KPR peptide;

^**PLSK peptide; AHNAK: Desmoykin; G6PI, glucose 6 phosphoisomerase; MMP-1, matrix metalloproteinase 1; RA-A47, rheumatoid arthritis-related antigen 47 kDa.