Table 3.

Clinical observations during the first 8 h after induction of septic shock in rhesus monkeys.

Treatment	Animal ID	Clinical observation	Veterinarian
Group I PBS; termination after 8 h	Ri429	At 8 h the animal showed faecal vomiting and convulsions. No pulse and arrhythmia. An abnormal ECG. During the last hours the animal displayed forced respiration and decreased blood clotting as indicated by continued bleeding after blood extraction	No recovery allowed
	Ri274	A progressively decreasing heart rate and blood pressure was observed. The animal also developed arrhythmia. The oxygen saturation could hardly be measured and at the end decreased rapidly. The animal became increasingly unstable	No recovery allowed
	Ri8012	After administration of the Esherichia coli there was a rapid development of oedema above the eyes and also in the lungs. In the final phase the animal displayed forced respiration and bronchi at auscultation indicative of oedema of the lungs. Abnormal ECG. The animal became increasingly unstable	No recovery allowed
Group II Peptide cocktail; termination after 8 h	Ri459	The animal had a good pulse and a normal ECG. The heart sounded normal and lungs sounded clean. Although the animal displayed depressed respiration, the respiration was deep and regular	Recovery allowed
	Ri7046	The animal remained stable during the observation period. The animal developed mild oedema after infusion of Escherichia coli. The animal showed mild depressed respiration, but it was deep and regular	Recovery allowed
	Ri11152	Initial stable clinical parameters became less stable after infusion of Escherichia coli. After administration of Enrofloxacin a stable increased heart frequency was measured but blood pressure became difficult to assess. In the later phase of the disease oedema was diagnosed after auscultation, necessitating repositioning of the animal on his side so that the animal could breath more freely. In the final phase the lungs sounded normal but an abnormal ECG was measured	No recovery allowed
Group III Peptide cocktail; recovery allowed	Ri 427	The animal had a good pulse and a normal ECG. The heart sounded normal. The left lung displayed a slight murmur but overall sounded good. This animal had a normal regular respiration	Actually recovered
	C 152	The animal had a good pulse and a normal ECG. The heart sounded normal and the lungs sounded clean at 8 h. This animal had a normal respiration and stable clinical parameters	Actually recovered

ECG: electrocardiogram; PBS: phosphate-buffered saline.