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. 2010 May 25;102(11):1578–1591. doi: 10.1038/sj.bjc.6605683

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Copyright © 2010 Cancer Research UK

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DNA damage induction and repair profiles measured by the alkaline Comet assay in human tumour cell lines (A–C, A549; D–F, GaMG; G–I, HT 1080; and J–L, SNB19) pretreated with drugs (200 nM, 24 h) and irradiated with 8 Gy of X-rays in vitro. The extent of DNA damage was measured quantitatively by the comet Tail Moment (TM). Each point (bar) represents the mean value (±s.d.) of TM data measured in about 150 cells from two independent experiments and normalised against untreated controls (circles, dashed line). The curves are best least-square fits of a monoexponential function to the experimental data points. Numbers indicate the repair half-time constants (min) for each curve/treatment and the ratios of the repair half-time constants of drug-pretreated cells to control cells.

DNA damage induction and repair profiles measured by the alkaline Comet assay in human tumour cell lines (A–C, A549; D–F, GaMG; G–I, HT 1080; and J–L, SNB19) pretreated with drugs (200 nM, 24 h) and irradiated with 8 Gy of X-rays in vitro. The extent of DNA damage was measured quantitatively by the comet Tail Moment (TM). Each point (bar) represents the mean value (±s.d.) of TM data measured in about 150 cells from two independent experiments and normalised against untreated controls (circles, dashed line). The curves are best least-square fits of a monoexponential function to the experimental data points. Numbers indicate the repair half-time constants (min) for each curve/treatment and the ratios of the repair half-time constants of drug-pretreated cells to control cells.