Table 1. Correlation of clinicopathological parameters with the CAIX expression level detected by immunohistochemistry in 555 NSCLC patients.
|
CAIX status
|
||||
|---|---|---|---|---|
| Variables | Overall† | Low† | High† | P-value |
| Patient cohort | 555 | |||
| Mean age (years)‡ | 63.9±9.3 | 64.5±8.4 | 65.3±5.6 | 0.196 |
| Gender a | ||||
| Male | 415 (75) | 309 (74) | 106 (26) | 0.439 |
| Female | 140 (25) | 111 (79) | 29 (21) | |
| Smoking history a | ||||
| Never smoked | 75 (14) | 54 (72) | 21 (28) | 0.098 |
| Former or current smokers | 480 (86) | 366 (76) | 114 (24) | |
| Tumour size (cm)‡ | 3.7±2.4 | 3.8±2.3 | 4.1±2.1 | 0.293 |
| Histological cell type a | ||||
| Adenocarcinoma | 281 (50) | 245 ( 87) | 36 (13) | <0.001* |
| Squamous cell carcinoma | 184 (33) | 116 (63) | 68 (37) | |
| Large cell carcinoma | 43 (8) | 27 (63) | 16 (37) | |
| NOS | 47 (9) | 32 (68) | 15 (32) | |
| pTNM stage a | ||||
| I | 278 (50) | 221 (79) | 57 (21) | 0.676 |
| II | 103 (19) | 79 (77) | 24 (23) | |
| III | 151 (27) | 116 (77) | 35 (23) | |
| IV | 23 (4) | 16 (70) | 7 (30) | |
| Histological grade a | ||||
| 1 | 214 (38) | 168 (78) | 46 (22) | 0.785 |
| 2 | 187 (34) | 143 (76) | 44 (24) | |
| 3 | 137 (25) | 101 (74) | 36 (26) | |
| 4 | 17 (3) | 13 (76) | 4 (24) | |
| Neoadjuvant therapya | 67 (12) | 62 (92) | 5 (8) | 0.105 |
Abbreviations: NOS = not otherwise specified; TNM = tumour node metastasis.
†Values expressed as n (%) or mean±s.d.
a
χ2-test.
‡Mann–Whitney test.
*P-value significant at the 0.05 level.