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. Author manuscript; available in PMC: 2010 Jun 10.
Published in final edited form as: Infect Disord Drug Targets. 2010 Jun;10(3):226–239. doi: 10.2174/187152610791163336

Fig. 1.

Fig. 1

De novo pyrimidine biosynthetic pathway in Plasmodium. The pathway involves six enzymes: a bifunctional glutamine amidotransferase (GAT) and carbamoyl-phosphate synthetase (CPS), aspartate carbamoyltransferase (ACT), dihydroorotase (DHOtase), dihydroorotate dehydrogenase (DHODH), orotate phosphoribosyltransferase (OPRT) and orotidine-5’-monophosphate decarboxylase (OMPDC). L-Gln, L-glutamine; CP, carbamoyl phosphate; Asp, L-aspartic acid; CA, carbamoyl aspartate; DHO, dihydroorotate; OA, orotic acid; OMP, orotidylate; UMP, uridylate. Enzyme names are displayed in blue. The rescue pathway used to bypass mitochondrial PfDHODH in transgenic parasites harboring yeast DHODH is displayed in grey.