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. Author manuscript; available in PMC: 2010 Jun 10.
Published in final edited form as: Infect Disord Drug Targets. 2010 Jun;10(3):226–239. doi: 10.2174/187152610791163336

Table 3.

Structure activity of 2,5 substituted thiofurans.

graphic file with name nihms207003t18.jpg
Structures PfDHODH
IC50 (µM)		 Pf 3D7 cells
EC50 (µM)
8 graphic file with name nihms207003t19.jpg 0.042 0.49
28 graphic file with name nihms207003t20.jpg 0.46 0.71
29 graphic file with name nihms207003t21.jpg 0.7 0.47
30 graphic file with name nihms207003t22.jpg 0.17 0.63
31 graphic file with name nihms207003t23.jpg >30 >10
32 graphic file with name nihms207003t24.jpg >30 >10
33 graphic file with name nihms207003t25.jpg >30 >10

Data taken from [75]. Assay conditions were described in Table 1