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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Future Med Chem. 2010 May 1;2(5):757–774. doi: 10.4155/fmc.10.179

Figure 6. Determination of VU590 structure–activity relationships through combinatorial chemistry and thallium-flux assays.

Figure 6

(A) VU590 and areas to explore through chemical optimization. (B) Structure–activity relationship of VU590 analogs. (C) Alternate capping agents used to attenuate the basicity of VU590.

Reproduced with permission from [47].