TABLE 1.

EFFECT OF DIFFERENT PROCESSING VARIABLES ON CHARACTERISTICS OF TOLMETIN SODIUM MICROPARTICLES

parameter	Formulation	Process variable	Production yield (%±SD)	Theoretical drug content (%)	Mean drug entrapped (%±SD)	Mean particle size (μm±SD)	Drug loading efficiency (%±SD)
Drug to polymer ratio	F1	0.25:1	58.6±4.24	20	19.7±3.21	189.90±0.21	98.35±3.35
	F2a	0.5:1	40±1.24	33.33	33.1±3.56	209.02±0.19	99.40±6.31
	F3	0.75:1	28.6±3.58	42.85	45.1±5.65**	279.30±0.20	105.32±1.32
	F4	1:1	23.3±3.13	50	51.5±3.15	401.01±0.16	103.06±3.15
Stirring rate (rpm)	F2-1	500	48.8±3.80	33.33	35.9±3.75	470.05±0.18	107.78±6.25
	F2-2a	1000	40.0±1.24	33.33	33.3±3.56	209.02±0.20	99.40±6.31
	F2-3	2000	55.6±6.19	33.33	34.7±3.46	113.53±0.17	104.32±7.23
Emulsifier concentration %	F2-4a	0.5	40±1.24	33.33	33.1±3.56	209.02±0.90	99.40±6.31
	F2-5	1	78.9±7.68	33.33	32.8±4.47	198.98±0.19	98.35±5.24
	F2-6	2	43.3±6.59	33.33	32.3±2.33	190.30±0.11	97.06±3.56
Volume of dispersing medium (ml)	F2-7a	50	40±1.24	33.33	33.1±3.56	209.02±0.20	99.40±6.31
	F2-8	100	50±4.58	33.33	27.2±5.51	140.10±0.20	81.74±4.65**
	F2-9	200	55±6.35	33.33	17.1±0.21	135.77±0.15	51.23±2.35

^aF₂ is selected formulation and process variable was performed on it. F₂-2, F₂-4 and F₂-7 are the same as F₂ formulation