Figure 1.
Chromaffin cell genes involved in catecholamine biosynthesis, storage, secretion and degradation. Depicted are important chromaffin cell-expressed genes and functional relationships between them. Two different parameters are color coded: the heritability (H2) of transcript abundance as computed from the RI panel and the normalized ratio (NR) for differences between the progenitors (on the left and right side of each box, respectively). The red curved arrow represents the catecholamine biosynthetic pathway, with the intermediates also in red. The blue curved arrows represent the detected gene regulatory networks from eQTL analysis, pointing from the regulator to the regulated gene.