Table 1.
Biochemical phenotypes measured in adrenal tissue homogenate
| Phenotype | SHR (mean ± SD) | BN.Lx (mean ± SD) | SHR versus BN.Lx t-test P-value | NRSHR/BN.Lx | H2 in RI strains |
|---|---|---|---|---|---|
| DA (ng/mg) | 1.92 ± 0.46 | 1.41 ± 0.23 | 0.048 | 1.4 | 63% |
| Dbh (nmol/h/mg) | 1.24 ± 0.24 | 2.23 ± 0.35 | 0.001 | −1.8 | 46% |
| NE (ng/mg) | 67.6 ± 10.9 | 97.6 ± 8.07 | 0.002 | −1.4 | 35% |
| Pnmt (pmol/h/mg) | 33.0 ± 3.09 | 43.3 ± 3.29 | 0.001 | −1.3 | 34% |
| EPI (ng/mg) | 191 ± 27.8 | 191 ± 20.6 | 0.994 | 1.0 | 36% |
| Cort (IU/mg) | 466 ± 146 | 244 ± 73.1 | 0.024 | 1.9 | 15% |
HXB/BXH RI strains and the progenitor strains, SHR and BN.Lx, were typed for catecholaminergic biochemical parameters in the adrenal gland. The table shows progenitor strain means ± SD, t-test P-value for progenitor strain differences, normalized ratio (NR) to indicate the direction of the progenitor strain difference, and heritability (H2) calculated from RI strain data. Biochemical parameters were normalized to milligram adrenal weight. No significant differences in the mean adrenal gland weight (maw) were observed between the progenitor strains, with mawSHR = 16.0 ± 3.0 mg, mawBN.Lx = 13.5 ± 1.9 mg and t-test P = 0.18.
DA, dopamine; NE, norepinephrine; EPI, epinephrine; Cort, corticosterone.