Table 2.

Expression QTL mapping results for chromaffin cell-expressed genes with heritable transcript levels in the HXB/BXH RI strains

Gene transcript					Mapped expression QTLs
Transcript (probe ID)	gene symbol	gene position (Chr:Mbp)	progenitor t-test P-val	H2 in RI (%)	eQTL position (Chr:Mbp)	eQTL type	LOD	P-value	% variance attributable to eQTL	genes of interest in the 95% CI
1387075_at	Th	1:203	0.0365	48	8:80	Trans	2.51	0.176
1368064_a_at	Ddc	14:93	0.0002	70	14:45	Trans	3.43	0.040	42
1370564_at	Dbh	3:6	0.0216	64	3:6	Cis	5.58	0.006	60	Dbh
1371054_at	Pnmt	10:87	0.4492	60	10:90	Cis	2.95	0.049	36	Pnmt
1387999_at	Vmat1	16:22	0.4263	23	10:90	Trans	3.33	0.041	43	Pnmt
1387235_at	Chga	6:127	0.1854	36	10:87	Trans	2.68	0.093	35	Pnmt
1373510_at	Vamp1	4:161	0.0213	53	4:161	Cis	3.50	0.072	43	Vamp1
1368826_at	Comt	11:85	0.0130	24	4:149	Trans	2.71	0.318
1368034_at	Chgb	3:121	0.7601	25	8:80	Trans	3.11	0.124
1368044_at	Scg2	9:79	0.1274	49	5:16	Trans	2.11	0.674
1387154_at	Npy	4:78	0.0031	26	17:78	Trans	2.14	0.426
1387221_at	Gch	15:23	0.1691	39	19:48	Trans	2.12	0.320
1367695_at	Qdpr	14:71	0.2837	28	10:99	Trans	3.12	0.149

Genes with heritable transcripts (see Fig. 1, coded yellow/orange) were included. Results for each transcript consist of LOD-peak position, eQTL type, LOD score and P-value. For the significant—including marginally significant—eQTLs (bolded P-values), the proportion of the variance in transcript level attributable to the eQTL is also given. The last column indicates chromaffin cell-expressed genes within the 95% CI of the mapped eQTLs.

Probe ID, affymetrix RAE 230A probe set ID; eQTL, expression QTL; H² = heritability calculated in the HXB/BXH RI strains; LOD, logarithm of odds; 95% CI, 95% confidence interval for eQTL position.