Table 1.

Eyes injected subretinally with rAAV5-GFP or rAAV5-hCNGB3

Promoter/vector construct	Dog ID/gender	Eye	Age at Tx (weeks)	Vol. (µl)	Conc. (vg ml−1)	Studies and gene expression longest follow-up period (weeks)
						ERG	Obstacle	Morphology/IHC	qRT-PCR
PR0.5-hCNGB3	M577/m	L	4	60	1.53 × 1014	11		33
	GS80/m	L	8	70	1.53 × 1014	39	56	74
3LCR-PR0.5-GFP	M582/m	R	7	110	2.55 × 1012	10		25
	M583/m	R	7	110	2.55 × 1012	31		38
3LCR-PR0.5- hCNGB3	M583/m	L	7	110	7.48 × 1012	4		39
	GS89/f	L	8	110	7.48 × 1012	115			115
	M608/m	L	9	120	1.73 × 1012	3		5
	M596/f	R	23	140	5.28 × 1012	37			37
	M574/f	L	28	110	2.05 × 1012	31			88
	M589/m	R	60	140	5.28 × 1012	34			36
	M575/f	R	81	120	1.73 × 1012	30			38
PR2.1-GFP	M570/m	L	6	80	8 × 1014			4
	M573/f	L	3	90	1.36 × 1013			4
PR2.1-hCNGB3	M606/m	R	3	120	9.43 × 1012	27			41
	GS118/f	L	7	130	8.47 × 1010	27		28
	GS94/m	L	10	80	7.23 × 1012	130	42
	M598/m	L	11	110	4.33 × 1012	48			48
		R	11	130	4.33 × 1012	48			48
	GS99/f	L	12	120	1.29 × 1013	45			45
	M625/m	R	12	110	9.39 × 1012	9		12
	M617/m	R	13	110	1.65 × 1013	45
	M584/m	L	14	180	7.23 × 1012	130	42
	M625/m	L	17	150	8.67 × 1012	4		7
	M626/m	L	17	190	8.67 × 1012	9	8		26
		R	17	190	8.67 × 1012	9	8		26
	M627/m	L	17	140	6.50 × 1012	4	5		26
		R	17	140	8.67 × 1012	4	5		26
	GS87/m	R	54	150	7.73 × 1012	44			44
	GS89/f	R	54	150	7.73 × 1012	68			68
	GS80/m	L	66	160	7.28 × 1012	4		16

All dogs with M prefix in ID are Alaskan Malamute-derived and are homozygous for the genomic deletion of CNGB3 (CNGB3^−/−). All dogs with the GS prefix are derived from German Shorthaired Pointer and are homozygous for the D262N missense mutation of CNGB3 (CNGB3^m/m).