Table 1.
Association between the type of PATRR22 polymorphism and total frequency of de novo translocations
| Case | Genotype of AT-rich region | PATRR11 genotype | Template DNA (ng/µl) | Positive PCR | Translocation frequencya |
|---|---|---|---|---|---|
| 1 | A/C | L/L | 100 | 23/44 | 2.24 × 10−5 |
| 2b | A/C | L/L | 50 | 30/50 | 5.55 × 10−5 |
| 3 | A/C | L/L | 100 | 10/50 | 6.76 × 10−6 |
| 4b | B/C | L/L | 50 | 39/50 | 9.18 × 10−5 |
| 5 | B/C | L/L | 100 | 35/51 | 3.51 × 10−5 |
| 6b | B/C | L/L | 10 | 21/50 | 1.65 × 10−4 |
| 7 | C/C | L/L | 100 | 33/71 | 1.89 × 10−5 |
| 8 | C/C | L/L | 100 | 17/26 | 3.21 × 10−5 |
| 9 | C/C | L/L | 100 | 18/39 | 1.88 × 10−5 |
| 14b | A/A | L/AS | 10 | 7/50 | 4.57 × 10−5 |
aThe total frequency was calculated based on the total number of positive PCR.
bThe first two examinations of these samples showed positive results in almost all of the aliquots, precluding the estimation of the exact frequency of the translocation. We therefore used 50 ng (Cases 2 and 4) and 10 ng (Cases 6 and 14) of DNA as a template in these cases.