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Patient 3: A 44-year-old woman with melasma was treated with 4-n-butylresorcinol 0.1% cream, and her MI decreased from 223.00 to 189.33 (-33.67). The clinical presentation at baseline with the MI: 223.00 (A), after 4 weeks with the MI: 197.33 (B) and after 8 weeks with the MI: 189.33 (C).