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High concentrations of soluble farnesol (3 and 30 mM) inhibit spreading of MC3T3-E1 pre-osteoblastic cells. MC3T3-E1 cells were incubated on titanium alloy discs without or with the indicated concentrations of farnesol for two days. The cellular morphology was assessed with fluorescence microscopy following staining with Texas Red-X phalloidin and DAPI (magnification, 20×).
