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. 2010 Jun 10;5(6):e11022. doi: 10.1371/journal.pone.0011022

Figure 4. Sox2 overexpression during mouse lung development leads to epithelial hyperplasia and adenocarcinoma.

Figure 4

(A) Section of control 15 week post-natal Rosa26-Sox2-IRES-GFP lung stained with H&E. (B) High-power region of bronchus and adjacent alveoli of (A). (C) Section of an SFTPC-Cre; Rosa26-Sox2-IRES-GFP transgenic mouse lung 15 weeks after birth stained with H&E. (D) A higher power view showing adenocarcinoma. (A,C) Scale bars = 200 microns. (B,D) Scale bars = 50 microns.