Figure 4. Sox2 overexpression during mouse lung development leads to epithelial hyperplasia and adenocarcinoma.
(A) Section of control 15 week post-natal Rosa26-Sox2-IRES-GFP lung stained with H&E. (B) High-power region of bronchus and adjacent alveoli of (A). (C) Section of an SFTPC-Cre; Rosa26-Sox2-IRES-GFP transgenic mouse lung 15 weeks after birth stained with H&E. (D) A higher power view showing adenocarcinoma. (A,C) Scale bars = 200 microns. (B,D) Scale bars = 50 microns.
