Table 2.
Association of the GSNOR SNPs and 5 SNP haplotypes with asthma and related phenotypes in Puerto Rican asthma families before correction for multiple testing. A stratified analysis was also performed for those subjects who were using albuterol as their only asthma medication.
| SNP Genotype (Allele Frequency, Allele) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| +3207 CT+TT/CC (0.26, T) | +16701 GA+AA/GG (0.10, A) | +16777 TG+GG/TT (0.37, G) | +17059 TG+GG/TT (0.11, G) | +17250 AG+GG/AA (0.16, G) | ||||||
| p-value | OR (95% CI) or Mean (SD) | p-value | OR (95% CI) or Mean (SD) | p-value | OR (95% CI) or Mean (SD) | p-value | OR (95% CI) or Mean (SD) | p-value | OR (95% CI) or Mean (SD)) | |
| All Puerto Rican Subjects (n = 336) | ||||||||||
| Asthma | 0.05 (+) | 1.17 (1.03 - 1.57) | 0.04 (+) | 1.35 (1.05 - 2.02) | 0.42 (+) | 1.08 (0.97 - 1.45) | 0.007 (+) | 1.41 (1.10 - 2.10) | 0.01 (+) | 1.40 (1.15 - 1.97) |
| Pre-FEV1 | 0.23 (-) | 83.6 (17.4)/84.9 (16.4) | 0.88 (-) | 84.2 (19.6)/84.5 (16.3) | 0.80 (+) | 83.9 (17.9)/84.7 (16.2) | 0.82 (+) | 85.7 (21.5)/83.6 (15.6) | 0.27 (+) | 85.2 (20.1)/84.1 (15.6) |
| ΔFEV1 | 0.13 (-) | 5.2 (12.9)/7.4 (10.2) | 0.85 (+) | 7.2 (14.2)/6.4 (13.2) | 0.39 (-) | 6.5 (15.0)/7.1 (10.6) | 0.93 (+) | 7.5 (14.4)/6.5 (13.0) | 0.69 (-) | 7.2 (13.3)/6.4 (13.4) |
| Puerto Rican Subjects using albuterol only (n = 168) | ||||||||||
| Asthma | 0.19 (+) | 1.18 (0.93 - 1.78) | 0.20 (+) | 1.38 (0.89 - 2.52) | 0.50 (+) | 1.13 (0.90 - 1.70) | 0.09 (+) | 1.44 (0.94 - 2.54) | 0.02 (+) | 1.68 (1.15 - 2.78) |
| Pre-FEV1 | 0.96 (+) | 88.1 (15.4)/85.9 (14.0) | 0.24 (+) | 92.5 (17.5)/85.2 (14.1) | 0.90 (+) | 86.8 (17.0)/86.2 (13.0) | 0.11 (+) | 93.3 (17.7)/84.4 (13.9) | 0.17 (+) | 91.8 (17.1)/84.5 (14.0) |
| ΔFEV1 | 0.01 (-) | 3.4 (7.2)/7.3 (10.3) | 0.03 (-) | 2.9 (6.4)/7.1 (15.4) | 0.49 (-) | 6.4 (16.4)/6.7 (10.7) | 0.01 (-) | 2.9 (6.3)/7.4 (15.5) | 0.01 (-) | 3.9 (6.9)/7.3 (15.9) |
“+” and “-” indicate direction of association. “+” indicates increased risk for asthma or higher value of the quantitative phenotypes Pre-FEV1 and ΔFEV1 whereas “-” indicates decrease risk for asthma and lower value of the quantitative phenotypes. p < 0.1 are shown in bold.