Table 3.
Association of the GSNOR 5 SNP haplotypes with asthma and related phenotypes in Puerto Rican asthma families before correction for multiple testing. A stratified analysis was also performed for those subjects who were using albuterol as their only asthma medication.
| 5 SNP Haplotype (Frequency) | ||||||
|---|---|---|---|---|---|---|
| C.G.T.T.A (0.63) | T.G.G.T.A (0.14) | T.A.G.G.G (0.10) | C.G.G.T.A (0.06) | C.G.G.T.G (0.05) | ||
| p-value | ||||||
| All Puerto Rican Subjects (n = 336) | ||||||
| Asthma | 0.67 (-) | 0.71 (+) | 0.02 (+) | 0.38 (-) | 0.89 (-) | |
| Pre-FEV1 | 0.50 (+) | 0.26 (-) | 0.74 (-) | 0.64 (-) | 0.55 (+) | |
| ΔFEV1 | 0.53 (+) | 0.11 (-) | 0.59 (+) | 0.90 (+) | 0.35 (-) | |
| Puerto Rican Subjects using albuterol only (n = 168) | ||||||
| Asthma | 0.73 (-) | 0.65 (+) | 0.17 (+) | 0.21 (-) | 0.32 (+) | |
| Pre-FEV1 | 0.76 (-) | 0.19 (-) | 0.10 (+) | 0.56 (+) | 0.44 (-) | |
| ΔFEV1 | 0.06 (+) | 0.42 (-) | 0.19 (-) | 0.40 (-) | 0.34 (-) | |
“+” and “-” indicate direction of association. “+” indicates increased risk for asthma or higher value of the quantitative phenotypes Pre-FEV1 and ΔFEV1 whereas “-” indicates decrease risk for asthma and lower value of the quantitative phenotypes. p < 0.1 are shown in bold.