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. 2010 Jun 10;5(6):e11041. doi: 10.1371/journal.pone.0011041

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Kapoor et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The graph shows accumulation levels of these substrates relative to WT-CaMDR1-GFP. The grey colored bars (no border) indicate levels of accumulation for [³H] MTX while empty bars (black border) indicate that for NR. Controls AD1-8u^- and CaMdr1p-GFP have also been included for comparison. The accumulation assays with [³H] FLU gave similar results as [³H] MTX for all the mutant variants (data not shown). The results are means ± standard deviations for three independent experiments.