Table 3. Results of replication in the TwinsUK cohort of the three revealed loci on disc area with their meta-analyzed results of all five cohorts.

Most significant SNP	Minor allele	Minor allele frequency	Chromosome location	Position	delta disc area per allele (mm2)		P-value	delta disc area per allele in meta-analysis of all five cohorts (mm2)		P-value in meta-analysis of all five cohorts
Disc area					Beta	SE		Beta	SE
rs1900004	T	0.24	10q21.3-q22.1	69670887	−0.133	0.038	4.64×10−4 *	−0.070	0.006	2.71×10−35 **
rs1192415	G	0.18	1p22	91849685	0.091	0.041	2.60×10−2 *	0.065	0.006	2.77×10−28 **
rs1362756	C	0.30	16q12.1	50015791	0.097	0.037	8.29×10−3 *	0.030	0.005	5.07×10−9 **

*Significant at a p-value of 0.05.

**Significant at a p-value of 5×10⁻⁸; SNP = single nucleotide polymorphism; SE = standard error.