Table 4. Results of top SNPs of all associated loci with p-value <10⁻⁶ on vertical cup-disc ratio in the meta-analysis for each individual cohort and the meta-analysis itself (results are presented as the effects per minor allele).

SNP	Chromosome location	Position	MA	RS-I/RS-II				RS-III				ERF				Meta-analysis				Name	Distance (b)	Number of SNPs on loci with p-value <10−6
				MAF	Beta	SE	P-value	MAF	Beta	SE	P-value	MAF	Beta	SE	P-value	MAF	Beta	SE	P-value
rs1063192	9q21	21993367	G	0.45	−0.014	0.002	6.15×10−11*	0.46	−0.013	0.005	1.38×10−2	0.47	−0.015	0.005	2.54×10−3	0.46	−0.014	0.002	1.96×10−14*	CDKN2B	0	88
rs10483727	14q22-23	60142628	T	0.40	0.014	0.002	2.93×10−10*	0.39	0.001	0.005	7.81×10−1	0.45	0.014	0.005	4.95×10−3	0.41	0.012	0.002	9.30×10−11*	SIX1	39878	10
rs17146964	11q13	65005721	G	0.21	−0.014	0.003	7.94×10−8	0.21	−0.013	0.007	5.65×10−2	0.21	−0.010	0.006	1.05×10−1	0.21	−0.014	0.002	4.43×10−9*	SCYL1	43403	8
rs1547014	22q12.1	27430711	T	0.29	−0.011	0.002	7.20×10−6	0.30	−0.019	0.006	1.02×10−3	0.32	−0.010	0.005	7.34×10−2	0.29	−0.011	0.002	1.96×10−8*	CHEK2	0	29
rs1900004	10q21.3-q22.1	69670887	T	0.22	−0.012	0.003	4.49×10−6	0.23	−0.021	0.006	8.90×10−4	0.21	−0.007	0.006	2.98×10−1	0.22	−0.013	0.002	2.06×10−8*	ATOH7/PBLD	9021	10
rs1926320	13q13	35550617	C	0.24	0.011	0.003	1.45×10−5	0.25	0.020	0.006	1.29×10−3	0.27	0.008	0.006	1.41×10−1	0.24	0.012	0.002	4.85×10−8*	DCLK1	0	15
rs8068952	17q23	56641426	G	0.24	−0.012	0.003	7.85×10−6	0.24	−0.014	0.006	2.54×10−2	0.20	−0.007	0.006	2.47×10−1	0.23	−0.012	0.002	3.11×10−7	BCAS3	0	2
rs12025126	1p36.2-p36.1	8682141	C	0.28	−0.009	0.003	3.93×10−4	0.27	−0.011	0.006	6.62×10−2	0.32	−0.019	0.005	3.82×10−4	0.29	−0.011	0.002	4.14×10−7	RERE	0	5
rs2159128	19p13.3	901380	G	0.13	−0.016	0.005	3.16×10−4	0.14	−0.021	0.010	3.67×10−2	0.11	−0.032	0.011	2.45×10−3	0.13	−0.019	0.004	7.05×10−7	ARID3A	0	1

* = Significant at a p-value of 5×10⁻⁸; SNP = single nucleotide polymorphism; MA(F) = minor allele (frequency); SE = standard error.