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. 2010 Jun 10;6(6):e1000951. doi: 10.1371/journal.ppat.1000951

Figure 10. The interaction of EBNA3A and EBNA3C with CtBP is necessary for the chromatin remodelling associated with the repression of p16INK4A.

Figure 10

(A) & (B) ChIP analysis of H3K27me3 and H3K4me3 in p16INK4A exon 1 (site C) performed in duplicate (assays i & ii) on an E3CtBP LCL, a 3ACtBP and a 3CCtBP. Similar analysis of a WT-EBV LCL is shown for comparison. (C) & (D) ChIP anaysis of H3K27me3 and H4Kme3 distribution across the p16INK4A-ARF locus in an E3CtBP LCL. Similar assays performed on revertant (revCtBP) and WT-EBV LCLs are shown for comparison. The sites correspond to those shown in Figure 5A.