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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Eur J Cancer. 2010 Mar 18;46(9):1668–1678. doi: 10.1016/j.ejca.2010.02.017

Figure 2.

Figure 2

EM011 perturbs spindle architecture and manipulates multipolar mitosis. Panel shows immunofluorescence confocal micrographs of prostate cancer cells stained for microtubules (green, FITC) and DNA (red, PI) upon 25 μM EM011 treatment for noted hours. There was an accumulation of mitotic cells in prometaphase (white arrowheads) with multipolar spindles at 24 hr of drug-exposure. At 48 hr of EM011 treatment, some multinucleate cells (open arrowhead) were evident and apoptotic bodies (white arrows) were visible at 48 and 72 hr.