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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Gastroenterology. 2010 Mar 10;138(7):2426–2436.e3. doi: 10.1053/j.gastro.2010.02.059

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VSG resulted in loss of body weight in males (A, P < 0.01 vs. SHAM and NAÏVE) and females (B, P < 0.05 vs. SHAM and NAÏVE) at all time points measured. Body weight change was equivalent for SHAM and NAÏVE rats at all time points (P > 0.05). (Overall interaction of time vs. surgical treatment: P = 0.0042 for males, P < 0.0001 for females.) Weight loss after VSG was due to loss of fat tissue (C, P < 0.001 vs. SHAM or NAÏVE for both male and female rats; overall effect of surgical treatment, P < 0.0001). Lean tissue was not affected by surgical treatment (D, P > 0.05 for overall effect of treatment and for all male-male or female-female comparisons). Daily food intake was suppressed immediately following VSG in both males (E, P < 0.001 vs. SHAM and NAÏVE until Day 16) and females (F, P < 0.001 vs. SHAM and NAÏVE until Day 16, P < 0.05 vs. SHAM on Day 24). After Day 16 for males and Day 24 for females, daily caloric intake did not differ between groups (P > 0.05 for all group comparisons).

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