Table 1.
Summary of vector insertion site characteristics versus random in silico-generated integration datasets (n.s. = non significant).
CatPac vector (n=184) | Matching Random | p-value | Control MoMLV (n=175) | Matching Random | p-value | p-value CatPac vector vs. MoMLV | |
---|---|---|---|---|---|---|---|
Sites inside of a gene (w/in exon or intron) | 49.5% | 32.9% | p < 0.0001 | 54.3% | 33.0% | p < 0.0001 | p ≤ 0.4181 (n.s.) |
Sites inside of a gene and w/in exon | 11.0% | 3.2% | p ≤ 0.0031 | 3.2% | 3.2% | p ≤ 0.4793 (n.s.) | p ≤ 0.0709 (n.s.) |
Sites inside of a gene and w/in intron | 89.0% | 96.8% | p ≤ 0.0031 | 96.8% | 96.7% | p ≤ 0.4793 (n.s.) | p ≤ 0.0709 (n.s.) |
Sites w/in 30 kb upstream of 1 or more genes | 25.0% | 12.3% | p < 0.0001 | 26.9% | 12.3% | p < 0.0001 | p ≤ 0.7787 (n.s.) |