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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: J Mol Cell Cardiol. 2010 Feb 6;49(1):41–47. doi: 10.1016/j.yjmcc.2010.02.001

Figure 1.

Figure 1

Infarct size in isolated rat hearts. All hearts were subjected to 30 min regional ischemia followed by 2 h of reperfusion. NECA (100 nM, n = 7) given at reperfusion reduced infarct size compared the control (n = 6). The anti-infarct effect of NECA was partially but significantly inhibited by the zinc chelator TPEN (10 μM, n = 6) and ZnCl2 (5 μM, n = 6) in the presence of the zinc ionophore pyrithione (Pyr, 2 μM) limited infarct size. TPEN (n = 6) and ZnCl2 (n = 6) alone did not alter infarct size. * p < 0.05 vs. control; # p < 0.05 vs. NECA