TABLE 6.
Uni- and multivariate analysis of the association between Mamu-KIR1D, KIR2DL4, KIR3DL and KIR3DH loci with plasma viral loads in SIV infected rhesus macaques
| Genotypes | HVL (n) | LVL (n) | OR | 95%CI | p-value | |
|---|---|---|---|---|---|---|
| lower | upper | |||||
| 1D*ITIM/*ITIM | 4 | 1 | 1.33 | 0.06 | 31.12 | 0.858 |
| 1D*null/*null | 3 | 1 | ||||
| 2DL4*1/*1 | 3 | 3 | 6.00 | 0.42 | 85.25 | 0.164 |
| 2DL4*2/*2 | 1 | 6 | ||||
| 3DH*h/*h | 7 | 1 | 21.67 | 0.64 | 730.08 | 0.047 |
| 3DH*l/*l | 0 | 3 | ||||
| 3DH*h/*z | 8 | 1 | 35.00 | 1.12 | 1094.79 | 0.015 |
| 3DH*l/*z | 0 | 4 | ||||
| 3DL*h/*h | 4 | 1 | 7.33 | 0.66 | 81.37 | 0.078 |
| 3DL*o/*o | 6 | 11 | ||||
| 1D*ITIM/*x+2DL4*1/*y | 6 | 3 | 7.86 | 0.28 | 217.12 | 0.182 |
| 1D*null/*x+2DL4*2/*y | 0 | 3 | ||||
| 1D*ITIM/*x+3DL*h/*a | 2 | 1 | 1.33 | 0.07 | 26.62 | 0.850 |
| 1D*null/*x+3DL*o/*a | 3 | 2 | ||||
| 2DL4*1/*y+3DH*h/*z | 6 | 0 | 11.00 | 0.08 | 1438.12 | 0.270 |
| 2DL4*2/*y+3DH*l/*z | 0 | 1 | ||||
| 2DL4*1/*y+3DL*h/*a | 5 | 0 | 14.14 | 0.57 | 352.02 | 0.064 |
| 2DL4*2/*y+3DL*o/*a | 3 | 6 | ||||
| 3DH*h/*z+3DL*h/*a | 5 | 1 | 21.00 | 0.64 | 690.03 | 0.053 |
| 3DH*l/*z+3DL*o/*a | 0 | 4 | ||||
| 3DH*h/*h+3DL*o/*o | 3 | 0 | 15.00 | 0.18 | 1236.28 | 0.192 |
| 3DH*l/*l+3DL*o/*o | 0 | 2 | ||||
| 3DH*h/*z+3DL*o/*a | 6 | 1 | 25.67 | 0.80 | 824.78 | 0.034 |
| 3DH*l/*z+3DL*o/*a | 0 | 4 | ||||
| 1D*ITIM/*x+2DL4*1/*y+3DL*h/*a | 2 | 0 | 3.00 | 0.02 | 473.1 | 0.665 |
| 1D*null/*x+2DL4*2/y+3DL*o/*a | 0 | 1 | ||||
| 2DL4*1/*y+3DH*h/*z+3DL*h/*a | 3 | 0 | 5.00 | 0.04 | 711.87 | 0.505 |
| 2DL4*2/*y+3DH*l/*z+3DL*o/*a | 0 | 1 | ||||
Abbreviation: 1D*ITIM is Mamu-KIR1D allele-3, 4, 5, 7, 8, 9 and 11; 1D*null is Mamu-KIR1D allele-1, 2, 6 and 10; 1D*x is Mamu-KIR1D allele-1 to allele-11; 2DL4*1 is Mamu-KIR2DL4 allele-1; 2DL4*2 is Mamu-KIR2DL4 allele-2; 2DL4*y is Mamu-KIR2DL4 allele-1 to allele-7; 3DH*h is Mamu-KIR3DH allele-2, 3, 6, 10, 11, 13, and 14; 3DH*l is Mamu-KIR3DH allele-4, 5, and 12; 3DH*z is Mamu-KIR3DH allele-1 to allele-14; 3DL*h is Mamu-KIR3DL allele-13 and 14; 3DL*o is Mamu-KIR3DL allele-1 to allele-12 and variant A; 3DL*a is Mamu-KIR3DL allele-1 to allele-14 and variant A; OR is the odds ratio; and CI is confidence interval