Table 1. Lung cancer CT screening: results of observational studies.
Lung cancers
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Subjects | Age (years) a | NSM b | p-y c | CT lesions d | Baseline e | Stage I f | First repeat g | |
Henschke et al, 1999 | 1000 | 67 | 0 | 45 | 233 (23) | 27 (2.7) | 85 | — |
Sone et al, 2001 | 5483 | 64 | 54 | — | 588 (11) | 23 (0.4) | 100 | 27 (0.5) |
Nawa et al, 2002 | 7956 | 56 | 38 | — | 541 (7) | 36 (0.5) | 78 | 4 (0.1) |
Sobue et al, 2002 | 1611 | 59 | 14 | — | 186 (12) | 14 (0.9) | 71 | 22 (1.4) |
Diederich et al, 2004 | 817 | 53 | 0 | 45 | 350 (43) | 12 (1.5) | 64 | — |
Swensen et al, 2003 | 1520 | 59 | 0 | 45 | 780 (51) | 27 (1.7) | 74 | 13 (0.9) |
Pastorino et al, 2003 | 1035 | 58 | 0 | 40 | 199 (19) | 11 (1.1) | 55 | 11 (1.1) |
Bastarrika et al, 2005 | 911 | 55 | 0 | 30 | 291 (32) | 12 (1.3) | 83 | 2 (0.2) |
Chong et al, 2005 | 6406 | 55 | 23 | — | 2,255 (35) | 23 (0.4) | 56 | — |
Novello et al, 2005 | 519 | 59 | 0 | — | 241 (47) | 5 (1.0) | 67 | 3 (0.6) |
MacRedmond et al, 2006 | 449 | 55 | 0 | 45 | 111 (25) | 2 (0.4) | 50 | 4 (0.9) |
I-ELCAP 2006 | 31 567 | 61 | 17 | 30 | 4186 (13) | 410 (1.3) | 85 | 74 (0.2) |
Veronesi et al, 2008 | 5201 | 58 | 0 | 44 | 2754 (53) | 55 (1.1) | 66 | 37 (0.7) |
Overall | 64 475 | 59 | 20 | — | 12 715 (20) | 657 (1.0) | 81 | 197 (0.3) |
Abbreviations: CT=computed tomography; NSM=non-smokers; p-y=pack-years.
Median age of participants.
Proportion of non-smokers.
Median pack-years.
Subjects with suspicious non-calcified solid lesions (percentage of participants).
Lung cancers detected at baseline (percentage of participants).
Percentage of lung cancers detected in stage I at baseline.
Lung cancers detected at first annual CT repeat.