Table 3. Univariate analyses of clinicopathologic parameters on recurrence-free and overall survival in patients with adenocarcinoma.
Adenocarcinoma (n=222)
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Recurrence-free survival
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Overall survival
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Variables | N (%) | 5-year rate (%) | P-value | 5-year rate (%) | P-value |
Age, years | |||||
As continuous variable | 222 (100) | 0.153 | 0.073 | ||
<30 | 5 (2.3) | 80 | 0.250 | 80 | 0.096 |
30–49 | 141 (63.5) | 89 | 93 | ||
>50 | 76 (34.2) | 81 | 86 | ||
FIGO stage | |||||
IA2 | 8 (3.6%) | 100 | <0.001 | 100 | <0.001 |
IB1–IB2 | 195 (87.8%) | 89 | 92 | ||
IIA | 19 (8.6%) | 52 | 65 | ||
Histologic subtype | |||||
Mucinous | 203 (16.7%) | 87 | 0.373 | 90 | 0.425 |
Endometrioid | 14 (1.1%) | 77 | 84 | ||
Serou | 2 (0.2%) | 50 | 50 | ||
Mixed | 3 (0.2%) | 100 | 100 | ||
Grade of differentiation a | |||||
Well | 63 (29.0) | 88 | 0.688 | 90 | 0.532 |
Moderately | 94 (43.3) | 83 | 91 | ||
Poorly | 60 (27.6) | 87 | 89 | ||
Tumour size, cm | |||||
⩽2 | 108 (48.6) | 91 | 0.041 | 95 | 0.033 |
2–4 | 94 (42.3) | 82 | 85 | ||
4–6 | 20 (9.0) | 77 | 90 | ||
>6 | 0 (0.0) | — | — | ||
Depth of stromal invasion | |||||
⩽1/2 | 135 (60.8) | 92 | 0.002 | 94 | 0.008 |
>1/2 | 87 (39.2) | 78 | 84 | ||
Parametrial involvement | |||||
No | 200 (90.1) | 89 | <0.001 | 92 | <0.001 |
Yes | 22 (9.9) | 55 | 66 | ||
Resection margin | |||||
Negative | 218 (98.2) | 87 | 0.013 | 91 | 0.005 |
Positive | 4 (1.8) | 38 | 38 | ||
LVSI | |||||
No | 189 (85.1) | 88 | 0.033 | 92 | 0.026 |
Yes | 33 (14.9) | 75 | 80 | ||
Lymph node metastasis | |||||
No | 188 (84.7) | 90 | <0.001 | 94 | <0.001 |
Yes | 34 (15.3) | 66 | 69 | ||
Adjuvant treatment | |||||
None | 159 (71.6) | 89 | 0.003 | 94 | <0.001 |
Chemotherapy | 20 (9.0) | 88 | 95 | ||
Radiation therapy | 26 (11.7) | 76 | 77 | ||
CCRT | 11 (7.7) | 71 | 70 |
Abbreviations: CCRT=concurrent chemoradiation therapy; FIGO=International Federation of Obstetrics and Gynecology; LVSI=lymphovascular space invasion.
Grade of differentiation was undetermined in 21 patients.