Table 4. Univariate analyses of clinicopathologic parameters on recurrence-free and overall survival in patients with squamous cell carcinoma.
Squamous cell carcinoma (n=996)
|
|||||
---|---|---|---|---|---|
Recurrence-free survival
|
Overall survival
|
||||
Variables | N | 5-year rate (%) | P-value | 5-year rate (%) | P-value |
Age, years | |||||
As continuous variable | 996 (100) | <0.001 | <0.001 | ||
<30 | 16 (1.6) | 94 | <0.001 | 94 | <0.001 |
30–49 | 574 (57.6) | 94 | 97 | ||
>50 | 406 (40.8) | 88 | 91 | ||
FIGO stage | |||||
IA2 | 80 (8.0) | 100 | 0.002 | 100 | 0.061 |
IB1–IB2 | 824 (82.7) | 92 | 94 | ||
IIA | 92 (9.3) | 83 | 91 | ||
Grade of differentiation a | |||||
Well | 269 (27.4) | 92 | 0.705 | 93 | 0.896 |
Moderately | 479 (48.8) | 92 | 94 | ||
Poorly | 234 (23.8) | 90 | 93 | ||
Tumour size, cm | |||||
⩽2 | 463 (46.5) | 97 | <0.001 | 98 | <0.001 |
2–4 | 416 (41.8) | 89 | 92 | ||
4–6 | 94 (9.4) | 80 | 87 | ||
>6 | 23 (2.3) | 75 | 77 | ||
Depth of stromal invasion | |||||
⩽1/2 | 618 (62.0) | 94 | <0.001 | 95 | 0.001 |
>1/2 | 378 (38.0) | 87 | 91 | ||
Parametrial involvement | |||||
No | 906 (91.0) | 93 | <0.001 | 95 | <0.001 |
Yes | 90 (9.0) | 78 | 82 | ||
Resection margin | |||||
Negative | 972 (97.6) | 92 | 0.399 | 94 | 0.170 |
Positive | 24 (2.4) | 96 | 100 | ||
LVSI | |||||
No | 780 (78.3) | 93 | <0.001 | 95 | 0.003 |
Yes | 216 (21.7) | 87 | 90 | ||
Lymph node metastasis | |||||
No | 860 (86.3) | 93 | <0.001 | 95 | <0.001 |
Yes | 136 (13.7) | 82 | 85 | ||
Adjuvant treatment | |||||
None | 748 (75.1) | 94 | <0.001 | 96 | <0.001 |
Chemotherapy | 66 (6.6) | 89 | 91 | ||
Radiation therapy | 87 (8.7) | 84 | 87 | ||
CCRT | 95 (9.5) | 82 | 85 |
Abbreviations: CCRT=concurrent chemoradiation therapy; FIGO=International Federation of Obstetrics and Gynecology; LVSI, lymphovascular space invasion.
Grade of differentiation was undetermined in 21 patients.