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. 2010 Jun 8;102(12):1692–1698. doi: 10.1038/sj.bjc.6605705

Table 4. Univariate analyses of clinicopathologic parameters on recurrence-free and overall survival in patients with squamous cell carcinoma.

  Squamous cell carcinoma (n=996)
    Recurrence-free survival
Overall survival
Variables N 5-year rate (%) P-value 5-year rate (%) P-value
Age, years          
 As continuous variable 996 (100)   <0.001   <0.001
 <30 16 (1.6) 94 <0.001 94 <0.001
 30–49 574 (57.6) 94   97  
 >50 406 (40.8) 88   91  
           
FIGO stage          
 IA2 80 (8.0) 100 0.002 100 0.061
 IB1–IB2 824 (82.7) 92   94  
 IIA 92 (9.3) 83   91  
           
Grade of differentiation a
 Well 269 (27.4) 92 0.705 93 0.896
 Moderately 479 (48.8) 92   94  
 Poorly 234 (23.8) 90   93  
           
Tumour size, cm          
 ⩽2 463 (46.5) 97 <0.001 98 <0.001
 2–4 416 (41.8) 89   92  
 4–6 94 (9.4) 80   87  
 >6 23 (2.3) 75   77  
           
Depth of stromal invasion
 ⩽1/2 618 (62.0) 94 <0.001 95 0.001
 >1/2 378 (38.0) 87   91  
           
Parametrial involvement
 No 906 (91.0) 93 <0.001 95 <0.001
 Yes 90 (9.0) 78   82  
           
Resection margin
 Negative 972 (97.6) 92 0.399 94 0.170
 Positive 24 (2.4) 96   100  
           
LVSI          
 No 780 (78.3) 93 <0.001 95 0.003
 Yes 216 (21.7) 87   90  
           
Lymph node metastasis
 No 860 (86.3) 93 <0.001 95 <0.001
 Yes 136 (13.7) 82   85  
           
Adjuvant treatment
 None 748 (75.1) 94 <0.001 96 <0.001
 Chemotherapy 66 (6.6) 89   91  
 Radiation therapy 87 (8.7) 84   87  
 CCRT 95 (9.5) 82   85  

Abbreviations: CCRT=concurrent chemoradiation therapy; FIGO=International Federation of Obstetrics and Gynecology; LVSI, lymphovascular space invasion.

a

Grade of differentiation was undetermined in 21 patients.