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. 2010 Jun 8;102(12):1692–1698. doi: 10.1038/sj.bjc.6605705

Table 7. Univariate analyses of clinicopathologic parameters on recurrence-free and overall survival in all patients (n=1218).

    Recurrence-free survival
Overall survival
Variables No. of patients 5-year rate (%) P-value 5-year rate (%) P-value
Age, years          
 As continuous variable 1218 (100%)   <0.001   <0.001
 <30 21 (1.7%) 90 <0.001 90 <0.001
 30–49 715 (58.7%) 93   96  
 >50 482 (39.6%) 87   90  
           
FIGO stage          
 IA2 88 (7.2%) 100 <0.001 100 <0.001
 IB1–IB2 1019 (83.7%) 91   93  
 IIA 111 (9.1%) 80   86  
           
Histology          
 SCCa 996 (81.8%) 92 0.008 94 <0.001
 AdCa 222 (18.2%) 86   90  
           
Grade of differentiation a
 Well 332 (27.3%) 91 0.902 93 0.967
 Moderately 573 (47.0%) 91   94  
 Poorly 294 (24.1%) 89   92  
           
Tumour size, cm          
 ⩽2 571 (46.9%) 96 <0.001 97 <0.001
 2–4 510 (41.9%) 88   91  
 4–6 114 (9.4%) 80   87  
 > 6 23 (1.9%) 75   77  
           
Depth of stromal invasion
 ⩽1 out of 2 753 (61.8%) 94 <0.001 95 <0.001
 >1 out of 2 465 (38.2%) 85   90  
           
Parametrial involvement
 No 1106 (90.8%) 92 <0.001 95 <0.001
 Yes 112 (9.2%) 74   79  
           
Resection margin
 Negative 1190 (97.7%) 91 0.911 93 0.803
 Positive 28 (2.2%) 89   93  
           
LVSI          
 No 1048 (86.0%) 92 <0.001 94 <0.001
 Yes 170 (14.0%) 85   89  
           
Lymph node metastasis
 No 1111 (85.5%) 93 <0.001 95 <0.001
 Yes 188 (14.5%) 78   82  
           
Adjuvant treatment
 None 907 (74.5%) 93 <0.001 95 <0.001
 Chemotherapy 86 (7.1%) 89   92  
 Radiation therapy 113 (9.3%) 82   85  
 CCRT 112 (9.2%) 80   83  

Abbreviations: AdCa=adenocarcinoma; CCRT=concurrent chemoradiation therapy; FIGO=International Federation of Obstetrics and Gynecology; LVSI=lymphovascular space invasion; SCCa=squamous cell carcinoma.

a

Grade of differentiation was undetermined in 21 patients.