Table 7. Univariate analyses of clinicopathologic parameters on recurrence-free and overall survival in all patients (n=1218).
Recurrence-free survival
|
Overall survival
|
||||
---|---|---|---|---|---|
Variables | No. of patients | 5-year rate (%) | P-value | 5-year rate (%) | P-value |
Age, years | |||||
As continuous variable | 1218 (100%) | <0.001 | <0.001 | ||
<30 | 21 (1.7%) | 90 | <0.001 | 90 | <0.001 |
30–49 | 715 (58.7%) | 93 | 96 | ||
>50 | 482 (39.6%) | 87 | 90 | ||
FIGO stage | |||||
IA2 | 88 (7.2%) | 100 | <0.001 | 100 | <0.001 |
IB1–IB2 | 1019 (83.7%) | 91 | 93 | ||
IIA | 111 (9.1%) | 80 | 86 | ||
Histology | |||||
SCCa | 996 (81.8%) | 92 | 0.008 | 94 | <0.001 |
AdCa | 222 (18.2%) | 86 | 90 | ||
Grade of differentiation a | |||||
Well | 332 (27.3%) | 91 | 0.902 | 93 | 0.967 |
Moderately | 573 (47.0%) | 91 | 94 | ||
Poorly | 294 (24.1%) | 89 | 92 | ||
Tumour size, cm | |||||
⩽2 | 571 (46.9%) | 96 | <0.001 | 97 | <0.001 |
2–4 | 510 (41.9%) | 88 | 91 | ||
4–6 | 114 (9.4%) | 80 | 87 | ||
> 6 | 23 (1.9%) | 75 | 77 | ||
Depth of stromal invasion | |||||
⩽1 out of 2 | 753 (61.8%) | 94 | <0.001 | 95 | <0.001 |
>1 out of 2 | 465 (38.2%) | 85 | 90 | ||
Parametrial involvement | |||||
No | 1106 (90.8%) | 92 | <0.001 | 95 | <0.001 |
Yes | 112 (9.2%) | 74 | 79 | ||
Resection margin | |||||
Negative | 1190 (97.7%) | 91 | 0.911 | 93 | 0.803 |
Positive | 28 (2.2%) | 89 | 93 | ||
LVSI | |||||
No | 1048 (86.0%) | 92 | <0.001 | 94 | <0.001 |
Yes | 170 (14.0%) | 85 | 89 | ||
Lymph node metastasis | |||||
No | 1111 (85.5%) | 93 | <0.001 | 95 | <0.001 |
Yes | 188 (14.5%) | 78 | 82 | ||
Adjuvant treatment | |||||
None | 907 (74.5%) | 93 | <0.001 | 95 | <0.001 |
Chemotherapy | 86 (7.1%) | 89 | 92 | ||
Radiation therapy | 113 (9.3%) | 82 | 85 | ||
CCRT | 112 (9.2%) | 80 | 83 |
Abbreviations: AdCa=adenocarcinoma; CCRT=concurrent chemoradiation therapy; FIGO=International Federation of Obstetrics and Gynecology; LVSI=lymphovascular space invasion; SCCa=squamous cell carcinoma.
Grade of differentiation was undetermined in 21 patients.