Table 2.

NR3A loss-of-function and gain-of-function studies demonstrate reciprocal effects in mutant mice.

Measurement	NR3A-KO	NR3A-OE	References
Spine number and synapse size	↑	↓	Das et al., 1998; Roberts et al., 2009
Magnitude of NMDAR-mediated currents	↑	↓	Das et al., 1998; Perez-Otano et al., 2001; Sasaki et al., 2002; Tong et al., 2008; Roberts et al., 2009
NMDAR calcium permeability	↑	↓	Perez-Otano et al., 2001; Sasaki et al., 2002; Sucher et al., 2003; Tong et al., 2008
Hyperpolarization-mediated block of NMDAR currents by magnesium	↑	↓	Sasaki et al., 2002; Tong et al., 2008; Roberts et al., 2009
- LTP (3×100 Hz)	Early developmental onset	↓	Roberts et al., 2009
- LTD (1 Hz; 15 min)	No change	No change
Cell death after ischemic-hypoxic insults	↑	↓	Nakanishi et al., 2009
Spatial memory (Morris water maze)	ND	↓	Roberts et al., 2009
Long-term memory (food preference and object recognition)	ND	↓	Roberts et al., 2009
Sensorimotor gating (prepulse inhibition to startle)	↑ in males; no change in females	No change	Brody et al., 2005

Abbreviations: NR3A-KO, NR3A knockout mouse; NR3A-OE, NR3A overexpressor mouse; LTP, long-term potentiation; LTD, long-term depression; Hz, hertz; ND, no data.