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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Cancer Res. 2010 May 18;70(11):4778–4784. doi: 10.1158/0008-5472.CAN-09-4104

Figure 3. Effects of miR-92 manipulation on expression of ERβ1 and other target genes.

Figure 3

Using quantitative RT-PCR, suppression of miR-92 inhibits miR-92 gene expression in MCF-7 cells in a dose-dependent manner and after 48 hours resulted in upregulation of ERβ1 mRNA expression relative to negative controls (a) while overexpression of miR-92 led to downregulation of ERβ1 mRNA expression (b). MiR-92 silencing restored MUC16 expression (c). Each experiment was performed in triplicate with 3 experimental replicates. Each data point is the mean ± S.D. *P < 0.05, **P <0.001, ***P < 0.0001.