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. Author manuscript; available in PMC: 2010 Nov 15.
Published in final edited form as: Cancer Res. 2010 Apr 20;70(10):3861–3863. doi: 10.1158/0008-5472.CAN-10-0468

Figure 1. SUMO conjugation components regulate ubiquitin processes at chromatin around double-stranded DNA breaks.

Figure 1

The PIAS4 SUMO ligase is required for the accumulation of RNF168 and subsequent activity of RNF8:RNF168 ubiquitin ligases possibly through direct SUMOylation. 53BP1 SUMO conjugation depends on PIAS4.

The PIAS1 SUMO ligase is required for complete accumulation of BRCA1, possibly through RAP80, and PIAS1 and PIAS4 are both required for SUMOylation of BRCA1 which in turn increases its ubiquitin ligase activity.

Ubiquitin ligases are shown as green diamonds, and ubiquitin as green circles labelled “U”. SUMO ligases are shown as light blue ovals and SUMO as small light blue ellipses labelled “S”. Chromatin components are in orange.