Table 3.
Absolute bioavailability of CAT-354
| Geometric LSM | Ratio of LSM % (90% CI) | ||||
|---|---|---|---|---|---|
| Parameter | 150 mg i.v. | 150 mg s.c. | 300 mg s.c. | 150 mg s.c. : i.v. | 300 mg s.c. : i.v. |
| Cmax/D (µg ml−1 mg−1) | 0.379 | 0.109 | 0.115 | 28.7 (22.5, 36.6) | 30.3 (23.7, 38.6) |
| AUC(0,∞)/D (µg ml−1 day mg−1) | 5.70 | 3.54 | 3.43 | Absolute bioavailability*(90% CI) | |
| 62.1 (48.5, 79.6) | 60.1 (46.9, 77.1) | ||||
*
Assessed from geometric LSM ratios of AUC(0,∞)/D. LSM, least-square means; Cmax/D, dose-normalized maximum concentration after each infusion/injection; AUC(0.∞)/D, dose-normalized area under the serum concentration–time curve from time 0 to infinity.