Table 4.
Two-compartment model-estimated parameters for CAT-354 pharmacokinetics
| Parameter | Final estimates | SEE (%) |
|---|---|---|
| CL (ml day−1) | 186 | 13.5 |
| Vcentral (ml) | 3060 | 8.17 |
| Q (ml day−1) | 294 | 37.4 |
| Vperipheral (ml) | 1770 | 24.9 |
| F (%) | 66.2 | 12.4 |
| tlag (days) | 0.245 | 35.3 |
| ka1 (day−1) | 0.110 | 221 |
| ka2 (day−1) | 0.270 | 35.3 |
| Fraction Abs2 (%) | 0.847 | 69.4 |
CL, systemic clearance; Vcentral, volume of central compartment; Q, distributional clearance between central and peripheral compartments; Vperipheral, volume of peripheral compartment; F, absolute bioavailability; tlag, absorption lag time; ka1, first-order absorption rate constant; ka2, delayed first-order absorption rate constant; Fraction Abs2, fraction of CAT-354 absorbed by the delayed absorption process; SEE, standard error of the estimate.