Table 3.
NSAID exposure and odds ratios for the outcomes of interest
| Myocardial infarction | Peripheral arterial disease | Heart failure | Arrhythmias | Cardiac arrest | All-cause mortality | |
|---|---|---|---|---|---|---|
| OR* (95% CI) | OR* (95% CI) | OR* (95% CI) | OR* (95% CI) | OR* (95% CI) | OR* (95% CI) | |
| NSAID use | ||||||
| Not used in last 2 years | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Used 30 days–2 years | 0.97 (0.93, 1.01) | 1.01 (0.86, 1.19) | 0.96 (0.93, 0.99) | 0.99 (0.91, 1.06) | 0.86 (0.77, 0.97) | 0.94 (0.91, 0.96) |
| Used once or twice within the last 30 days | 1.07 (1.01, 1.14) | 0.96 (0.76, 1.22) | 0.93 (0.89, 0.98) | 0.85 (0.76, 0.96) | 0.87 (0.75, 1.06) | 0.65 (0.62, 0.69) |
| Use more than twice within the last 30 days | 1.30 (0.87, 1.94) | 0.70 (0.09, 5.17) | 1.14 (0.86, 1.52) | 1.27 (0.66, 2.44) | 1.32 (0.46, 3.76) | 0.93 (0.71, 1.23) |
*
Adjusted for age (to nearest year), residential aged care status (in RAC for at least 6 months prior to index date), public or private hospital admissions (for diabetes, obesity, dementia, hypertension, IHD, respiratory disease, liver disease, rheumatoid arthritis or renal disease) at any time prior to the index date, and the use of salicylic acid and derivatives or medications for the following conditions: obesity, diabetes, thrombosis, cardiovascular disease, dementia and obstructive airways diseases within 4 months prior to the index date.