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CpG treatment altered systemic immunoglobulin levels in TLR9–/– mice alone. ELISA analysis of serum IgE (a) and IgG2a (b) from Aspergillus-sensitized and conidium-challenged TLR9+/+ and TLR9–/– mice either untreated, or treated with IN or IP CpG. Serum was removed from all groups of mice on day 28 after conidium challenge. Means ± SEM; n = 10/group/time point.
