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. 2010 Jan 28;87(1):60–72. doi: 10.1093/cvr/cvq029

Figure 2.

Figure 2

Illustrations of intrinsic bradycardia and arrhythmias in ΔKPQ-SCN5A mice. (A) Telemetric ECG of pauses and atrioventricular block in unrestrained ΔKPQ-SCN5A mice. (B) Bradycardia-induced lethal torsades de pointes storm in an unrestrained ΔKPQ-SCN5A mouse. Within 30 min, 21 torsades de pointes episodes (duration 10 s–min) occurred. (C) Heart rate in unrestrained ΔKPQ-SCN5A and littermate WT mice during 24 h monitoring (mean ± SEM). ΔKPQ-SCN5A were bradycardic. (D) Propranolol decreased heart rates and blunted changes between rest during the day and activity at night and between genotypes. (E) Carbachol-induced episode of bradycardia with intermittent bigemini and torsades de pointes like arrhythmias in a ΔKPQ-SCN5A mouse.