Table 3.

The impact of parameters p and β on total hepatocyte number and the fraction of HCV-infected hepatocytes^*.

Viral- production rate p[virions day−1]	Infection rate constant β [ml virion−1 day−1]	Average number of infected hepatocytes (Ī) at baseline in 1,000 in-silico patients [106 cells/ml]	Average number of hepatocytes (Ī + T̄) at baseline in 1,000 in-silico patients [106 cells/ml]	% infected hepatocytes at baseline Ī / Ī (+ T̄) Mean(95% CI&)	Average infected cell death/loss rate ± SD δ (range: min – max) [1/day]	Average virion clearance rate ± SD c (range: min – max) [1/day]
0.1 – 6	10−9 to 10−8	5.25	8.98	58 (56 – 60)	0.03 ± 0.04 (0.001 – 0.36)	6.5 ± 5.5 (0.8 – 22.2)	Fig. 1A black bars
0.1 – 6	10−8 to1−7	5.88	8.14	73 (71 – 74)	0.09 ± 0.08 d (0.002 – 0.48)	9.7 ± 6.0 b (0.8 – 22)
0.1 – 6	10−7 to 1−6	5.87	6.50	90 (89 – 92)	0.13 ± 0.1 c (0.003 – 0.47)	11.2 ± 6.1 a (0.8 – 22.2)	Fig. 1B green bars
0.1 – 6	10−6 to 1−5	5.57	5.66	98 (97 – 99)	0.14 ± 0.1 c (0.002 – 0.48)	11.4 ± 6.2 a (0.8 – 22.2)
0.1 – 45	10−9 to 1−8	5.77	8.27	70 (68 – 72)	0.08 ± 0.08 d (0.002 – 0.43)	9.3 ± 6.1 b (0.8 – 22.2)	Fig. 1B blue bars

^*All other model parameters were randomly chosen within the ranges given in Table 1. Since we excluded parameter sets that lead to negative baseline values of virus (V), as explained in online supplemental material, the resulting parameter values of the virus clearance rate, c, and infected cell death rate, δ, were significantly different among some groups with different p and β ranges.

^**SD, one standard deviation.

^&CI, confidence interval.

^{a, b, c, d}, In post-hoc analyses, groups marked with the same superscript letter were not significantly different from each other; but were significantly different (p<0.01 allowing for Bonferroni correction) from all the other groups in the same column.