Fig. 6.
Sequence alignment of C-terminal tails of human Cav1.3 and Cav1.4 L-type channels: a sequence alignment of human Cav1.3 (Genbank accession number EU363339) and Cav1.4 (Genbank accession number AJ224874) α1 subunits is shown. Sequence identity (blue) and gaps (-) are indicated. Regions previously shown to be important for channel modulation by CaM in other voltage-gated Ca2+ channel isoforms are depicted (EF hand, pre-IQ, and IQ domain). The position of long and short Cav1.3 channels is indicated by black arrows (Cav1.3L and Cav1.3S, respectively). Position of the Cav1.4 CTM is given in yellow; - indicates residues absent in this sequence