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Brugada syndrome. a Coved-type ST segment elevation in the right-precordial ECG leads V1 and V2 after intravenous (i.v.) administration of sodium channel blocking drug ajmaline in an individual with BrS. b BrS-linked SCN5A mutations often lead to peak sodium current reduction. c Reduced peak sodium current decreases the upstroke velocity of action potential phase 0, which slows cardiac electrical conduction
