Table 3.
Literature reports of PFS/OS for MTX-based multidrug chemotherapy
| Refs. | No. | Treatment | OS (months) | PFS (months) | Neuro-toxicity |
|---|---|---|---|---|---|
| [24] | 28 | MTX, ARA-C and 14 pts received CCNU, ARA = C, and melphalan with stem-cell rescue | Not yet reached (median FU: 28 months) | 5.6 (14 pts without transplantation) and 9.3 (14 pts with transplantation) | None |
| [25] | 50 | MTX, BCNU, PCZ, methylprednisolone, ARA-C | 14.3 (95% CI, 6.2–42) | 10.6 | 6 pts |
| [26] | 74 | MTX, dexamethasone and CPA or VP-16; PCZ in addition (for 44 patients) | 40.7 | 77.4 for pts <60 yo | Reversible neuro deficit (7), stroke (5), seizures (1), cerebral herniation (1), death w/in 30 days (4) |
| 18 months for pts >60 yo | |||||
| [27] | 52 | MTX, VCR, PCZ then WBXRT then ARA-C (22 without XRT) | 60 | FU duration too short | 13 pts |
| [28] | 39 | MTX, CPA, PCZ | 41 | – | None |
| [29] | 14 | MTX, Thio, VCR, dexamethasone, i.i.t. ARA-C | Not yet reached | 16.5 | 13 events |
| [30] | 19 | MTX, VCR, PCZ or MTX, VCR, PCZ, ARA-C or MTX, Thio | 30.5 | Not yet reached | 1 pt |
| [31] | 65 | MTX, ARA-C, Dex, VCR, iIfos, CPA, prednisolone | 50 | 21 | 2 pts with cog dysfunction, 20 with MRI white matter lesions, 11 with peripheral neuropathy, 6 deaths |
| [32] | 64 | MTX, CCNU, PCZ, methylprednisolone, ARA-C | Not yet reached (54 month median FU) | 13 | 6 pts |
| [33] | 23 | MTX, Temo | 35 | 8 | None |
| [34] | 102 | MTX, VCR,PCZ, WBXRT then ARA-c | 36.9 | 24 | 4 pts, 12 of 82 receiving XRT |
| [35] | 112 | (1) WBXRT; (2) MVP; (3) proMACE-MOPP; or (4) R-MTX | 24 | 16 | – |
| [36] | 52 | MBVP and RT | 46 | – | 1 pt |
| [37] | 54 | HDMTX, CCNU, PCZ; or HDMTX, dex (and Ifos, ARA-C) | 41.4 | 9 | 14 pts (some received WBXRT) |
Ref reference, FU follow-up, PFS progression-free survival, OS overall survival, (HD) MTX (High-dose) methotrexate, (WB) XRT whole-brain radiation, RT radiation therapy, R-MTX radiation with methotrexate, ARA-C cytosine arabinoside, BCNU carmustine, CCNU lomustine, dex dexamethasone, PCZ procarbazine, Thio thiotepa, Temo temodar, VP16 etoposide, proMACE-MOPP prednisone, methotrexate, adriamycin, cyclophosphamide, etoposide, mechlorethamine, vincristine, procarbazine, MVP mitomycin, vinblastine, cisplatin, MBVP methotrexate, teniposide, carmustine, methylprednisolone, CI confidence interval, yo years old