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. 2010 May 26;4:71. doi: 10.1186/1752-0509-4-71

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Copyright ©2010 Na et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The use of a genetic algorithm to design synthetic RDS sequences having specific translational efficiencies. The RDS design process starts with a user-specified 5' untranslated region (UTR) and a coding sequence (CDS). The 10 nucleotides upstream of the start codon, which make up part of the RDS, are modified to satisfy a target translational efficiency using a genetic algorithm. The generated sequences are randomly mutated or crossed over. If the translational efficiency of the generated sequences converges to the target efficiency, the algorithm terminates.