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. 2010 Apr 30;9:98. doi: 10.1186/1476-4598-9-98

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Copyright ©2010 Wang et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Recurrent co-regulated gene networks in patient cancer samples. The set of Par-4-modulated genes with NFκB sites identified in HT29 colon cancer cells were analyzed in patient cancer sample microarray data to define recurrent co-regulated gene networks. (A) Colon cancer recurrent co-regulated network of 240 genes with 311 links. (B) Prostate cancer recurrent co-regulated network of 276 genes with 367 links. A subset of Par-4-modulated genes identified in HT29 cells can also be found in a recurrent co-regulated network in prostate cancer samples. This suggests that Par-4 co-regulates overlapping genes with NFκB sites in both colon and prostate cancer samples. Red and green nodes indicate genes that were found to be up- or down-regulated by Par-4 in HT29 cells, respectively.