Table 2.
Pharmacokinetic parameters of mycophenolic acid (MPA) and its glucuronide (MPAG) according to SLCO Single Nucleotide Polymorphisms (SNPs) in patients co-treated with tacrolimus or sirolimus
| Gene | SNP | Genotypes (n) | MPA dn-C0 (mg/l)/g | MPA dn-Cmax (mg/l)/g | MPA Tmax (min) | MPA dn-AUC0-12h (mg.h/l)/g | MPAG dn-C0 (mg/l) | MPAG dn-Cmax (mg/l) | MPAG Tmax (min) | MPAG dn-AUC0-9h (mg.h/l) |
|---|---|---|---|---|---|---|---|---|---|---|
| SLCO1B3 | T334G | TT (n= 2) | 3.4±0.6 | 21.4±10.5 | 65.0±35.3 | 73.9±30.2 | 79.6±42.7 | 111.6±32.8 | 90.0±42.4 | 621.7±235.3 |
| TG (n=20) | 5.3±2.8 | 28.6±10.7 | 71.5±111.6 | 82.6±32.6 | 91.0±51.0 | 137.4±54.0 | 114.5±112.1 | 964.8±457.6 | ||
| GG (n=48) | 3.7±3.1 | 20.6±16.7 | 69.6±86.7 | 57.5±30.2 | 108.8±74.7 | 173.7±98.7 | 123.3±75.6 | 1146.2±644.2 | ||
| p values | 0.0413 | 0.0012 | 0.8113 | 0.0040 | 0.6296 | 0.3664 | 0.3297 | 0.2477 | ||
| p values (TT+TG vs GG) | 0.0150 | 0.0004 | 0.8233 | 0.0009 | 0.3774 | 0.1947 | 0.1364 | 0.2394 | ||
| G767C | GG (n=49) | 4.4±3.2 | 23.5±13.2 | 63.5±74.5 | 68.5±33.4 | 103.9±72.1 | 157.2±82.7 | 117.9±88.1 | 1042.6±524.5 | |
| GC (n=21) | 3.7±2.7 | 21.5±19.8 | 85.2±126.0 | 57.4±30.0 | 100.9±60.2 | 171.7±101.7 | 124.3±83.5 | 1165.1±741.9 | ||
| p values | 0.3153 | 0.1644 | 0.9183 | 0.2234 | 0.9365 | 0.5010 | 0.6570 | 0.4769 | ||
| SLCO1B1 | T521C | TT (n=47) | 3.6±2.3 | 22.1±17.0 | 64.0±75.7 | 60.0±30.0 | 112.3±76.3 | 170.0±96.7 | 116.6±84.1 | 1137.9±639.8 |
| TC (n=23) | 5.3±4.1 | 24.6±11.6 | 82.2±121.0 | 75.8±35.6 | 84.8±44.7 | 144.3±66.6 | 126.5±91.8 | 959.7±482.2 | ||
| p values | 0.0942 | 0.0902 | 0.6753 | 0.0534 | 0.1168 | 0.2685 | 0.9695 | 0.2578 | ||
| A388G | AA (n=19) | 4.0±2.5 | 18.5±9.0 | 80.0±115.2 | 58.2±30.4 | 123.9±93.7 | 167.8±95.9 | 117.4±114.9 | 1079.4±545.2 | |
| AG (n=43) | 4.0±3.3 | 23.7±16.3 | 71.6±89.9 | 65.9±33.0 | 91.0±55.7 | 156.6±87.1 | 127.4±75.5 | 1054.0±634.9 | ||
| GG (n=8) | 5.2±3.1 | 29.4±20.5 | 37.5±16.7 | 77.9±34.8 | 118.9±52.3 | 173.2±85.5 | 85.0±58.1 | 1164.6±542.6 | ||
| p values | 0.4849 | 0.1966 | 0.1858 | 0.2692 | 0.0883 | 0.6920 | 0.2154 | 0.5720 | ||
| C463A | CC (n=52) | 3.9±2.3 | 23.3±15.1 | 74.8±106.4 | 65.7±33.0 | 96.7±70.2 | 154.2±86.1 | 119.2±90.5 | 1015.1±562.9 | |
| CA (n=17) | 4.6±4.6 | 22.1±16.9 | 58.2±21.9 | 63.5±33.2 | 119.5±62.6 | 185.2±96.2 | 127.6±72.3 | 1291.0±672.6 | ||
| AA (n=1) | 8.6 | 18.3 | 20.0 | 62.9 | 137.0 | 145.6 | 20.0 | 824.9 | ||
| p values | 0.2799 | 0.7794 | 0.1598 | 0.9049 | 0.1393 | 0.3723 | 0.1249 | 0.1680 | ||
dn: dose-normalized