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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: J Hepatol. 2010 Apr 3;53(1):50–56. doi: 10.1016/j.jhep.2010.01.041

Fig. 2. CsA Disrupts the CypA-NS5A Interaction in a Dose-Dependent Manner.

Fig. 2

(A) Same as Fig. 4A, except that CsA (2.5 μM) was added to GST, GST-CypA and GST-H126Q CypA 15 min prior to the addition of NS5A Con1-His. (B) Same as A, except that increasing concentrations of CsA were used: 0 (lane 2), 0.3125 (lane 3), 0.625 (lane 4), 1.25 (lane 5) and 2.5 μM (lane 6). (C) Same as 1B. (D) Huh7 cells were co-transfected with pBIND, pact and pG5luc. Three days post-transfection, luciferase activity was measured in cell lysates. Data (triplicates) are representative of four independent experiments.