Table 1.
Demographics, HIV-infection related characteristics and prevalence of traditional risk factors at the time of the matching event8
| Cases (N=52) | Controls (N=104) | P | |
|---|---|---|---|
| Age | 50.8 ± 1.0 (32.2 – 62.8) | 50.8 ± 0.7 (31.1 – 65.1) | 0.97 |
| % Male | 98.0% | 98.0% | 1.0 |
| % African American | 19.2% | 14.4% | 0.48 |
| Exposure (% MSM) | 87.5% | 92.9% | 0.35 |
| Years of follow up | 8.2 ± 0.7 (0.5 – 19.5) | 8.6 ± 0.5 (1.0 – 20.1) | 0.61 |
| Years of HIV infection | 13.4 ± 0.7 (2.1 – 24.2) | 14.0 ± 0.5 (2.6 – 24.5) | 0.50 |
| Nadir CD4+ T cells/uL | 209 ± 21 (4 – 623) | 229 ± 15 (0 – 693) | 0.42 |
| Peak plasma HIV-RNA copies/mL | 4.3×105 ± 1.5×105 | 5.4×105 ± 1.4×105 | 0.40 |
| Years of ARV exposure | 8.9 ± 0.5 | 8.4 ± 0.4 | 0.67 |
| Years of PI exposure | 3.7 ± 0.4 | 4.0 ± 0.3 | 0.61 |
| % HCV co-infection | 13.5% | 13.5% | 1.0 |
| Dyslipidemia* | 87.0% | 71.9% | 0.05 |
| Use of lipid-lowering therapy | 34.6% | 23.1% | 0.13 |
| Hypertension** | 72.5% | 67.3% | 0.57 |
| Use of anti-hypertensive therapy | 38.5% | 24.0% | 0.06 |
| History of ever smoking | 58.8% | 52.5% | 0.46 |
| Current smoking at event | 49.0% | 25.0% | 0.004 |
| Diabetes | 15.4% | 12.7% | 0.62 |
| Family history of premature MI | 29.8% | 10.9% | 0.003 |
| BMI 4mo PTE (kg/m2) | 25.6 ± 0.5 | 25.6 ± 0.4 | 1.0 |
8
Shown are means and standard error with ranges in parentheses when appropriate.
Abbreviations used: MSM – men who have sex with men, ARV – antiretroviral, PI – protease inhibitor, HCV – hepatitis C virus, and PTE - prior to the event.