Table 3.
Serum and plasma markers of inflammation, endothelial insult, and thrombosis and cellular markers of T cell and monocyte activation10
| 4 months PTE | 2 years PTE | |||||
|---|---|---|---|---|---|---|
| Cases (N=40) |
Controls (N=87) |
P | Cases (N=40) |
Controls (N=86) |
P | |
| MDC (pg/mL) | 3470 ± 290 | 2880 ± 160 | 0.11 | 3360 ± 240 | 3000 ± 160 | 0.10 |
| Serum Amyloid A (ng/mL) | 5560 ± 1610 | 4490 ± 1250 | 0.06 | 8880 ± 4850 | 5220 ± 2500 | 0.03 |
| ICAM-1 (ng/mL) | 309 ± 15 | 306 ± 17 | 0.23 | 304 ± 20 | 296 ± 14 | 0.27 |
| VCAM-1 (ng/mL) | 7130 ± 2370 | 3770 ± 770 | 0.02 | 5170 ± 1380 | 3650 ± 1120 | 0.03 |
| hsCRP (ng/mL) | 570 ± 41 | 570 ± 26 | 0.60 | 570 ± 40 | 570 ± 26 | 0.47 |
| MPO (ng/mL) | 281 ± 39 | 205 ± 15 | 0.07 | 289 ± 32 | 210 ± 19 | 0.005 |
| D-dimer (ng/mL) | 482 ± 65 | 315 ± 20 | 0.003 | 505 ± 88 | 350 ± 44 | 0.04 |
| TIMP-1 (ng/mL) | 369 ± 12 | 332 ± 12 | 0.02 | 376 ± 28 | 327 ± 14 | 0.16 |
| NT-proBNP (pg/mL) | 48 ± 14 | 26 ± 3 | 0.08 | 60 ± 21 | 25 ± 2 | 0.09 |
| Eotaxin-3 (pg/mL) | 13.4 ± 1.4 | 12.9 ± 0.9 | 0.95 | 16 ± 1.3 | 18 ± 4.1 | 0.08 |
| IL-2 (pg/mL) | 1.5 ± 0.3 | 1.0 ± 0.1 | 0.21 | 1.6 ± 0.6 | 1.6 ± 0.6 | 0.87 |
| IL-6 (pg/mL) | 5.1 ± 1.2 | 3.4 ± 0.4 | 0.09 | 31 ± 27 | 3.8 ± 0.5 | 0.10 |
| IL-10 (pg/mL) | 65 ± 63 | 3.4 ± 0.4 | 0.88 | 163 ± 150 | 5.0 ± 2.0 | 0.27 |
| sCD14 (pg/mL) | 2.2 ± 0.07 | 2.2 ± 0.04 | 0.52 | |||
| sTF (pg/mL) | 38.5 ± 2.5 | 31.9 ± 1.2 | 0.02 | |||
| TNFa (pg/mL) | 20.9 ± 3.5 | 18.1 ± 2.3 | 0.29 | 26.1 ± 6.0 | 21.5 ± 2.8 | 0.08 |
| IFNy (pg/mL) | 1.7 ± 0.3 | 1.3 ± 0.1 | 0.83 | 1.7 ± 0.3 | 1.5 ± 0.2 | 0.55 |
| CD11c/CD36+ monocytes | 43.2 ±17.6% | 46.2 ±14.5% | 0.39 | 40.5 ±14.5% | 46.0 ±15.5% | 0.06 |
| CD8/PD-1+ T cells | 23.2 ±10.4% | 23.6 ±11.9% | 0.85 | 18.8 ± 6.6% | 22.4 ± 1.5% | 0.15 |
| CD4/CD38/HLADR+ T cells | 11.4 ± 2.2% | 10.0 ± 0.9% | 0.93 | 8.3 ± 0.8% | 10.0 ± 0.8% | 0.29 |
| CD8/CD38/HLADR+ T cells | 32.1 ± 2.3% | 30.7 ± 1.6% | 0.48 | 26.6 ± 2.1% | 29.8 ± 1.6% | 0.27 |
10
Abbreviations used – PTE – prior to the event; MDC – macrophage-derived chemokine (CCL22); ICAM-1 – intercellular adhesion molecule 1 (CD54); VCAM-1 – vascular cell adhesion molecule 1 (CD106); hsCRP – high sensitivity C-reactive protein; MPO – myeloperoxidase; TIMP-1 – tissue inhibitor of metalloproteinase 1; NT-proBNP – N-terminal fragment of brain natriuretic peptide; IL – interleukin; sCD14 – soluble CD14; sTF – soluble tissue factor; TNFα – tumor necrosis factor alpha; IFNγ – interferon gamma