Table 2.
RV-induced changes in gene expression: combined asthma and normal groups
| Gene symbol | Gene name | Biological function | Normal FDa | Asthma FDa |
|---|---|---|---|---|
| Upregulated genes | ||||
| CXCL3 | chemokine (C-X-C motif) ligand 3 | chemokine | 12.2 / 36.7 | 12.6 / 5.6 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | chemokine | 6.7 / 9.4 | 7.3 / 6.6 |
| IL8 | interleukin 8 | chemokine | 5.7 / 20.7 | 5.7 / 4.4 |
| CSF3 | colony stimulating factor 3 (granulocyte) | cytokine | 5.4 | 7.2 |
| IL1R2 | interleukin 1 receptor, type II | cytokine receptor | 5.1 | 7.5 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 | chemokine | 4.7 / 6.2 | 4.1 / 3.9 |
| EGR1 | early growth response 1 | transcription factor | 4.6 | 4.4 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | endopeptidase inhibitor | 4.4 | 5.3 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | inhibitor of apoptosis | 3.9 / 4.9 | 3.9 / 2.0 |
| CCL20 | chemokine (C-C motif) ligand 20 | chemokine | 3.8 / 5.7 | 4.5 / 3.8 |
| IL13RA2 | interleukin 13 receptor, alpha 2 | cytokine receptor | 3.7 | 4.7 |
| CSF2 | colony stimulating factor 2 (granulocyte-macrophage) | cytokine | 3.6 / 4.1 | 3.2 |
| IL1F9 | interleukin 1 family, member 9 | cytokine | 3.5 | 6.0 |
| SPRR2B | small proline-rich protein 2B | structural molecule | 3.1 | 4.5 |
| ZC3H12A | zinc finger CCCH-type containing 12A | transcription regulator | 3.1 | 3.2 |
| IL6 | interleukin 6 | cytokine | 2.9 / 5.6 | 3.7 |
| NFKBIZ | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | transcription regulator | 2.8 | 3.2 |
| 1558048_x_atb | cDNA clone IMAGE:4523513 | NA | 2.7 | 3.1 |
| S100A3 | S100 calcium binding protein A3 | calcium and zink binding | 2.7 | 2.6 / 2.0 |
| SOCS3 | suppressor of cytokine signaling 3 | JAK2 kinase inhibitor | 2.7 | 3.3 |
| Downregulated genes | ||||
| 225123_atb | FLJ33813 | NA | 9.1 | 8.4 |
| IVNS1ABP | influenza virus NS1A binding protein | response to virus | 8.6 | 8.3 |
| ITGB6 | integrin, beta 6 | receptor for fibronectin | 7.0 | 8.9 |
| DLG1 | discs, large homolog 1 (Drosophila) | cell-cycle regulation | 5.7 | 5.4 |
| TIA1 | TIA1 cytotoxic granule-associated RNA binding protein | inductor of apoptosis | 5.6 | 4.4 |
| FN1 | fibronectin 1 | ECM constituent | 5.6 | 4.1 |
| SLITRK6 | SLIT and NTRK-like family, member 6 | membrane protein | 5.4 | 4.2 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | protein modification | 5.3 | 5.2 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | lipid biosynthesis | 5.2 | 4.3 |
| UHRF2 | ubiquitin-like, containing PHD and RING finger domains, 2 | cell-cycle regulation | 5.0 | 4.4 |
| CDKN2B | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | cell-cycle regulation | 5.0 | 4.5 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | hydroxylation of lysyl residues in collagen | 5.0 | 4.7 |
| FLRT2 | fibronectin leucine rich transmembrane protein 2 | cell adhesion and/or receptor signaling | 4.9 | 5.2 |
| MAF | v-maf musculoaponeurotic fibrosarcoma oncogene homolog | transcription factor | 4.8 | 5.4 |
| GBP3 | guanylate binding protein 3 | GTP binding | 4.8 | 3.9 |
| SFRS12 | splicing factor, arginine/serine-rich 12 | splicing factor | 4.8 | 3.4 |
| KITLG | KIT ligand | ligand of the tyrosine- kinase receptor | 4.8 | 3.6 |
| SMC4 | structural maintenance of chromosomes 4 | chromosome organization | 4.8 | 2.7 |
| TTC37 | tetratricopeptide repeat domain 37 | binding | 4.8 | 3.1 |
| SLC39A10 | solute carrier family 39 (zinc transporter), member 10 | zink ion transport | 4.8 | 4.4 |
ECM, extracellular matrix; FD, fold difference (in expression); NA, not available; RV, rhinovirus.
a
Corresponding fold differences in expression (nominal P<0.05) generated by HG Focus microarray using cells from six additional donors (three normal and three asthmatic) are indicated after “slash”.
b
Affymetrix probe set ID is used when gene symbol is not available.